Project Description

Many interventions shown to be effective in clinical trials are never adopted in clinical settings. This study seeks to explore and address the reasons for non-adoption of an evidence-based psychosocial intervention (EBPI) that addresses anxiety, depression, and gastrointestinal (GI) symptoms among individuals with a common GI problem, irritable bowel syndrome (IBS). Approximately 30-50% of individuals with IBS report anxiety and depression, which is greater than the general population. IBS patients with anxiety and depression also report more severe IBS symptoms and lower quality of life than those without. However, an effective EBPI developed by our group has not been implemented outside of the experimental setting.

Using the Discover, Design, and Build framework, the purpose of this proposal is to 1) discover the barriers to clinical implementation from the perspective of both providers and patients and 2) iteratively develop a prototype to improve usability using a design-focused solution. Beginning with the original EBPI, which was designed and tested for in-person or telephone interactions, we will use focus groups with providers and patients to guide the re-design process and inform modifications to improve acceptability and usability.

SettingPrimary care and gastroenterology clinic settings
PopulationIndividuals with irritable bowel syndrome and comorbid anxiety and depression

Intervention and/or Implementation Strategy Designed or Redesigned

InterventionComprehensive self-management intervention addressing anxiety, depression, and gastrointestinal symptoms in individuals with IBS
Implementation StrategyFocus groups with providers and patients to guide re-design process and inform modifications to improve acceptability and usability of the original EBPI

Impact

The current EBPI has the potential to address adaptation of tested mental health treatments in other comorbid chronic conditions and improve the mental health of patients with chronic medical conditions. The intervention aims to provide structure, accountability, and support while addressing the gut-brain interaction comprehensively.

Project Publications

Impact of COVID-19 on Individuals With Irritable Bowel Syndrome and Comorbid Anxiety and/or Depression

Journal of Clinical Gastroenterology 56(2); 2022 · PubMed · Publisher

Authors

Kendra J Kamp, Rona L Levy, Sean A Munson, Margaret M Heitkemper

Abstract

Goals: The goal of this study was to describe the influence of the COVID-19 pandemic on ability to engage in activities and the influence on psychological distress and gastrointestinal symptoms among individuals with irritable bowel syndrome (IBS) and comorbid anxiety and/or depression.

Background: Individuals with IBS and comorbid anxiety and/or depression report increased symptoms and decreased quality of life compared to individuals with IBS alone. The current COVID-19 pandemic has the potential to further influence symptoms among individuals with IBS and comorbid anxiety and/or depression

Study: Individuals who met the Rome-IV IBS criteria and reported mild to severe anxiety and/or depression were included. Participants completed an online survey with questions about anxiety, depression, impact of COVID on activities and symptoms, and demographics.

Results: Fifty-five individuals participated in the study. The COVID-19 pandemic most commonly influenced their ability to spend time with friends and family, shop for certain types of food, and access healthcare. Participants also reported increased stress (92%), anxiety (81%), and depressive symptoms (67%). Finally, around half the sample reported increases in abdominal pain (48%), diarrhea (45%), or constipation (44%).

Conclusions: The COVID-19 pandemic is related to self-reported increases in psychological distress and gastrointestinal symptoms among individuals with IBS and comorbid anxiety and/or depression. Additional research is needed to intervene on these symptoms.

Symptom management needs of patients with irritable bowel syndrome and concurrent anxiety and/or depression: A qualitative study

Journal of Advanced Nursing 79(2); 2023 · PubMed · Publisher

Authors

Kendra J Kamp, Hailey Morgan, Linda Yoo, Sean A Munson, Margaret M Heitkemper, Rona L Levy

Abstract

Aims: To understand the experiences and needs of symptom management among individuals with irritable bowel syndrome and concurrent symptoms of anxiety and/or depression.

Design: This study used a qualitative descriptive research design.

Methods: Individuals with a diagnosis of irritable bowel syndrome and concurrent symptoms of anxiety and/or depression participated were recruited through an online ResearchMatch and a listserv. Semi-structured interviews focused on symptoms and experiences with symptom management interventions conducted from June to August 2020. Interviews were transcribed and data were analysed based on thematic analysis.

Results: Twelve individuals participated in this study; all reported current irritable bowel syndrome and anxiety/depression symptoms. The data analysis cumulated with three themes related to symptom management: (a) irritable bowel syndrome negatively impacts physical and mental well-being; (b) a trial and error approach to symptom management; and (c) challenges with healthcare professionals supporting symptom management including negative interactions with healthcare professionals and lack of nutritional expertize and support.

Conclusion: There is a need for individualized approaches which consider patients’ current symptoms of anxiety and depression, previous experiences with the trial-and-error process and consideration for intervention delivery methods.

Impact: There is a limited qualitative research focusing on the experiences of individuals with irritable bowel syndrome and concurrent symptoms of anxiety and/or depression. This research highlights the need for individualized approaches to enhance symptom management that acknowledges patients’ psychological state and past negative experiences with providers and prior dietary regimens.

Formative Evaluation of a Comprehensive Self-Management Intervention for Irritable Bowel Syndrome, Comorbid Anxiety, and Depression: Mixed Methods Study

JMIR Formative Research 2024;8 · PubMed · Publisher

Authors

Kendra Kamp , Pei-Lin Yang , Emily C. Friedman, Alejandra Lopez, Sarah Iribarren, Pamela Barney , Sean A Munson, Margaret Heitkemper, Rona Levy

Abstract

Background: Many teenagers in the United States experience challenges with symptoms of depression, and they lack adequate resources for accessing in-person mental health care. Involving teens and clinicians in designing technologies that use evidence-based practices that reduce barriers to accessing mental health care is crucial. Interventions based on behavioral activation (BA) help teens understand the relationship between mood and activity, help them practice goal-directed behaviors to improve mood, and may be particularly well-suited to delivery via internet-based platforms.

Objective: This study aims to understand the needs and challenges that teens and mental health clinicians face in depression management and involve them in the design process of a remote intervention that uses asynchronous remote communities. Our goal is to understand the benefits and challenges of adapting BA to an internet-based platform that supports the asynchronous remote community approach as a delivery tool for teen depression management.

Methods: We enrolled mental health clinicians (n=10) and teens (n=8) in separate, private, internet-based groups on Slack. They participated in 20-minute design activities for 10 weeks and were then invited to interviews about their experiences in the study.

Results: Both teen and clinician participants wanted internet-based support for BA as a supplement to in-person therapy. Although participants perceived the asynchronous format as conducive to supporting accessible care, teens and clinicians raised concerns about safety, privacy, and the moderating of the internet-based group. Design decisions that address these concerns need to be balanced with the potential benefits of learning coping skills, increasing access to mental health care, and promoting asynchronous human connection to support teens.

Conclusions: We discuss considerations for balancing tensions in privacy and safety while designing and selecting internet-based platforms to support remote care and integrating evidence-based support when designing digital technologies for the treatment of teens with depression.